Clinical application of chitin medical wound dressing paste

doi:10.3969/j.issn.2095-4344.2014.34.025

Abstract

Abstract:

BACKGROUND: The chitin medical wound dressing can relieve the wound pain, bleeding, and promote wound healing. It has good biocompatibility and antibacterial properties. With the good permeability and natural degradation in the body, it can be used clinically as a good biological wound dressing.

OBJECTIVE: To evaluate the clinical outcome of the chitin medical wound dressing paste and routine dressings used in changing the dressing and medication.

METHODS: We retrospectively studied 60 patients undergoing wound-treatment. They were divided into two groups: chitin medical wound dressing paste group and routine dressing group. Each group had 30 patients. We recorded wound healing rate, detection rate of bacteria, visual analog scale score, healing time and cost of treatment at 3, 7, 14 days after treatment.

RESULTS AND CONCLUSION: The wound healing rate, detection rate of bacteria, visual analog scale score, healing time of the chitin medical wound dressing paste group were better than those of the routine dressing change medicine group (P < 0.05). But there was no difference in the cost of treatment between the two groups. Therefore, we can made the conclusion that the chitin medical wound dressing paste used in changing the dressing and medication can promote wound healing, reduce the antibacterial infection rate, and obtain better treatment satisfaction.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: bandages, wound healing, chitosan

CLC Number:

R318

Zhang Jia, Hu Su-qin, Yan Lu, Wang Gui-ling. Clinical application of chitin medical wound dressing paste[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(34): 5555-5560.

Figures/Tables 3

References

[1] García JF,Del Mar Abad García M.Resource materials for the treatment of wounds. Rev Enferm.2013;36(2):20-31.
[2] Hackl F,Kiwanuka E,Philip J,et al.Moist dressing coverage supports proliferation and migration of transplanted skin micrografts in full-thickness porcine wounds. Burns.2014; 40(2):274-280.
[3] Junker JP,Kamel RA,Caterson EJ,et al.Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments.Adv Wound Care (New Rochelle).2013; 2(7): 348-356.
[4] Rusak A,Rybak Z.New directions of research related to chronic wound healing. Polim Med.2013;43(3):199-204.
[5] Meaume S,Dissemond J,Addala A,et al.Evaluation of two fibrous wound dressings for the management of leg ulcers: Results of a European randomised controlled trial (EARTH RCT).J Wound Care.2014;23(3):105-116.
[6] Co?kun G,Karaca E,Ozyurtlu M,et al.Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate aswound dressing in vivo.Biomed Mater Eng.2014;24(2):1527-1536.
[7] P T SK,Lakshmanan VK,Raj M,et al.Evaluation of wound healing potential of β-chitin hydrogel/nano zinc oxide composite bandage.Pharm Res. 2013;30(2):523-537.
[8] Kumar PT,Lakshmanan VK,Biswas R, et al.Synthesis and biological evaluation of chitin hydrogel/nano ZnO composite bandage as antibacterial wounddressing.J Biomed Nanotechnol. 2012;8(6):891-900.
[9] Zhou Y,Yang H,Liu X,et al.Potential of quaternization- functionalized chitosan fiber for wound dressing.Int J Biol Macromol.2013;52:327-332.
[10] Gholipour-Kanani A,Bahrami SH,Samadi-Kochaksaraie A,et al.Effect of tissue-engineered chitosan-poly(vinyl alcohol) nanofibrous scaffolds on healing of burn wounds of rat skin. IET Nanobiotechnol.2012;6(4):129-135.
[11] 鲁元刚,伍津津,朱堂友,等.复合壳多糖人工皮肤修复家兔全层皮肤缺损的实验研究[J].中华烧伤杂志,2002,18(1):19-22.
[12] Michalska M,Kozakiewicz M,Bodek KH.Polymer angiogenic factor carrier. Part I. Chitosan-alginate membrane as carrier PDGF-AB and TGF-beta[.Polim Med.2008;38(4):19-28.
[13] Waibel KH,Haney B,Moore M,et al.Safety of chitosan bandages in shellfish allergic patients.Mil Med.2011; 176(10): 1153-1156.
[14] Jang SI,Mok JY,Jeon IH,et al.Effect of electrospun non-woven mats of dibutyryl chitin/poly(lactic acid) blends on wound healing in hairless mice. Molecules.2012;17(3):2992-3007.
[15] Nacer Khodja A,Mahlous M,Tahtat D,et al.Evaluation of healing activity of PVA/chitosan hydrogels on deep second degree burn: pharmacological and toxicological tests.Burns. 2013;39(1):98-104.
[16] Francesko A,Tzanov T.Chitin, chitosan and derivatives for wound healing and tissue engineering.Adv Biochem Eng Biotechnol.2011;125:1-27.
[17] Jayakumar R,Prabaharan M,Sudheesh Kumar PT,et al. Biomaterials based on chitin and chitosan in wound dressing applications.Biotechnol Adv.2011;29(3):322-337.
[18] Wang Y,Zhang CL,Zhang Q,et al.Composite electrospun nanomembranes of fish scale collagen peptides/chito-oligosaccharides: antibacterial properties and potential for wound dressing.Int J Nanomedicine. 2011; 6: 667-676.
[19] 张秀菊,林志丹,陈文彬,等.新型聚乙烯醇/载药壳聚糖微球复合生物医用敷料的制备及临床应用[J].生物医学工程学杂志,2011,28(2):381-386.
[20] Murakami K,Ishihara M,Aoki H,et al.Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed ofchitin/chitosan, fucoidan, and alginate as wound dressings.Wound Repair Regen.2010; 18(5):478-485.
[21] 徐海栋,赵建宁,卢俊浩,等.基于生物材料创面敷料封闭负压引流在创伤性骨髓炎治疗中的应用[J].中国组织工程研究,2012, 16(12):2189-2192.
[22] 徐海栋,陈勇,卢俊浩,等.基于生物材料创面敷料封闭负压引流在四肢脱套伤治疗中的应用[J].中国组织工程研究,2012,16(34): 6445-6448.
[23] 徐海栋,陈勇,陆萌,等.基于生物材料创面敷料封闭负压引流在四肢毁损伤治疗中的应用[J].中国组织工程研究,2012,16(21): 3877-3880.
[24] 徐海栋,陈勇,赏后来,等.基于生物材料创面敷料封闭负压引流在骨筋膜室综合症切开减压中的应用[J].中国组织工程研究,2012, 16(8):1505-1508.
[25] 徐海栋,赵建宁,赏后来,等.生物材料创面敷料封闭负压引流在大面积创面植皮中的应用[J].中国组织工程研究,2012,16(3): 543-546.
[26] 徐海栋,赵建宁,卢俊浩,等.创面敷料封闭负压引流治疗慢性创面[J].中国组织工程研究,2013,17(16):3026-3032.
[27] 蒋琪霞,刘玉秀,印洪林,等.负压伤口治疗中2种填充敷料对伤口血管化和组织增殖活性的研究[J].医学研究生学报,2012,25(2): 175-179.
[28] 蒋琪霞,朱礼霞,李晓华,等.负压伤口治疗中两种填充敷料的研究进展[J].东南国防医药,2012,14(2):152-155.
[29] 何玲,于波,王慧丽,等,甲壳素/壳聚糖生物抗菌敷料在皮肤组织工程中的应用[J].中国组织工程研究与临床康复,2010,14(38): 7149-7152.
[30] Angspatt A,Tanvatcharaphan P,Channasanon S,et al.Comparative study between chitin/polyacrylic acid (PAA) dressing, lipido-colloid absorbent dressing and alginate wound dressing: a pilot study in the treatment of partial-thickness wound.J Med Assoc Thai.2010;93(6): 694-697.
[31] Dailey RA,Chavez MR,Choi D.Use of a chitosan-based hemostatic dressing in dacryocystorhinostomy.Ophthal Plast Reconstr Surg.2009;25(5):350-353.
[32] Wharram SE, Zhang X, Kaplan DL,et al. Electrospun silk material systems for wound healing.Macromol Biosci. 2010; 10(3):246-257.
[33] Sang LY,Zhou XH,Yun F,et al.Enzymatic synthesis of chitosan-gelatin antimicrobial copolymer and its characterisation.J Sci Food Agric.2010;90(1):58-64.
[34] Rescia VC,Takata CS,de Araujo PS,et al.Dressing liposomal particles with chitosan and poly(vinylic alcohol) for oral vaccine delivery.J Liposome Res.2011;21(1):38-45.
[35] Millner R,Lockhart AS,Marr R.Chitosan arrests bleeding in major hepatic injuries with clotting dysfunction: an in vivo experimental study in a model of hepatic injury in the presence of moderate systemic heparinisation.Ann R Coll Surg Engl.2010;92(7):559-561.
[36] Lu G,Ling K,Zhao P,et al.A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative.Wound Repair Regen.2010;18(1):70-79.
[37] Singh R,Chacharkar MP,Mathur AK.Chitin membrane for wound dressing application--preparation, characterisation and toxicological evaluation.Int Wound J. 2008;5(5):665-673.
[38] Madhumathi K,Sudheesh Kumar PT,Abhilash S,et al. Development of novel chitin/nanosilver composite scaffolds for wound dressing applications.J Mater Sci Mater Med.2010; 21(2):807-813.
[39] Bochicchio G,Kilbourne M,Kuehn R,et al.Use of a modified chitosan dressing in a hypothermic coagulopathic grade V liver injury model.Am J Surg.2009;198(5):617-622.
[40] Dai M,Zheng X,Xu X,et al.Chitosan-alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat.J Biomed Biotechnol.2009;2009:595126.
[41] Zhang X,Yang D,Nie J. Chitosan/polyethylene glycol diacrylate films as potential wound dressing material.Int J Biol Macromol.2008;43(5):456-462.
[42] Ong SY,Wu J,Moochhala SM,et al.Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials.2008; 29(32): 4323-4332.